Dapoxetine “On-Demand” for Premature Ejaculation: What Guidelines Say, What’s New, and What Are the Real Risks?
Selective serotonin reuptake inhibitors and tricyclic antidepressants in the acute treatment of chronic depression and dysthymia: A systematic review and meta-analysis. J Affect Disord 2013;144:7-15. Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. International society for sexual medicine’s guidelines for the diagnosis and treatment of premature ejaculation. Waldinger MD, Zwinderman AH, Olivier B. On-Demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, Double-Blind Fixed-Dose study with stopwatch assessment. A double-blind crossover trial of clomipramine for rapid ejaculation in 15 couples. An assessment of clomipramine (Anafranil) in the treatment of premature ejaculation. The efficacy of fluoxetine in the treatment of premature ejaculation: a Double-Blind placebo controlled study.
- It's essential to follow the prescribed dosage to prevent side effects.
- Dapoxetine is a prescription medication, so consultation is necessary.
- Combining dapoxetine with certain antidepressants may increase serotonin syndrome risk.
- The drug is considered effective for many men but may not work for all.
- Using dapoxetine can enhance relationships impacted by premature ejaculation.
- Regular medical check-ups are recommended during treatment.
Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study. A randomized double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients.
| Attribute | Description | Notes |
|---|---|---|
| Purpose | Delays ejaculation time during intercourse | Often prescribed for PE |
| Typical Dosage | 30 mg to 60 mg | Taken 1-3 hours before sex |
| Onset of Action | Within 1-3 hours | Peak effect approximately 1 hour after intake |
| Duration of Effect | 2 to 4 hours | Varies per individual |
| Common Side Effects | Nausea, dizziness, headache | Usually mild |
| Contraindications | Use with MAO inhibitors, severe cardiac issues | Consult doctor before use |
Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 2001;62 Suppl 3:10-21. SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fluvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. McCarty E, Dinsmore W.
Rights and permissions
Chronic thyroxine treatment activates the 5-HT2A serotonin receptor in the mouse brain. J Sex Med 2011;8:90-6. The relationship between premature ejaculation and hyperthyroidism. El-Nashaar A, Shamloul R. Antibiotic treatment can delay ejaculation in patients with premature ejaculation and chronic bacterial prostatitis.
Full Text Sources
J Sex Med 2007;4:491-6. Prevalence of chronic prostatitis in men with premature ejaculation. Prevalence of sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome. Psycho-biological correlates of free-floating anxiety symptoms in male patients with sexual dysfunctions. Social phobia and premature ejaculation: a case-control study. Dapoxetine: an evidence-based review of its effectiveness in treatment of premature ejaculation.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Viagra Generic | 25mg | 60 + 4 Pills | 71.99€ 68.56€ | |
| Kamagra | 100mg | 20 Pills | 86.09€ 81.99€ | |
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Tadalista Super Active | 20mg | 90 + 10 Pills | 314.14€ 299.18€ | |
| Viagra Generic | 100mg | 60 + 4 Pills | 96.36€ 91.77€ | |
| Viagra Oral Jelly | 100mg | 10 Sachets | 46.36€ 44.15€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ | |
| Kamagra Oral Jelly | 100mg | 21 Sachets | 95.92€ 91.35€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Viagra Generic | 50mg | 10 Pills | 26.87€ 25.59€ | |
| Levitra Soft Tabs | 20mg | 90 + 6 Pills | 241.31€ 229.82€ |
Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation.
PE and Erectile Dysfunction: A Common Overlap
Giuliano F, Clement P. Serotonin and premature ejaculation: from physiology to patient management. Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res 1998;92:111-8. J Sex Med 2011;8:316-27.
In this article:
Study of the efficacy of fluoxetine and clomipramine in the treatment of premature ejaculation after opioid detoxification. Adson DE, Kotlyar M. Premature ejaculation associated with citalopram withdrawal. The role of short frenulum and the effects of frenulectomy on premature ejaculation. Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis. Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal. Hiemke C, Hartter S. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacokinetics of selective serotonin reuptake inhibitors: clinical relevance. PAXIL® (paroxetine hydrochloride) Tablets and Oral Suspension [package insert].
How common is premature ejaculation?
Efficacy and safety of tramadol for premature ejaculation: a systematic review and meta-analysis. Wong BL, Malde S. The use of tramadol “on-demand” for premature ejaculation: a systematic review. Role of tramadol in premature ejaculation: a systematic review and meta-analysis. Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. ZOLOFT® (sertraline hydrochloride) Tablets and Oral Concentrate [package insert].
Medication in This Category
Psycho-Biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions. A prospective study comparing paroxetine alone versus paroxetine plus sildenafil in patients with premature ejaculation. Mattos RM, Marmo Lucon A, Srougi M. Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study. Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation.
Lifelong PE
Efficacy of sildenafil citrate (Viagra) in sildenafil and dapoxetine men with premature ejaculation. J Sex Med 2005;2:368-75. Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: a systematic review. Does current scientific and clinical evidence support the use of phosphodiesterase type 5 inhibitors for the treatment of premature ejaculation? Tramadol for the treatment of premature ejaculation. In vivo rat model to measure hypogastric nerve stimulation-induced seminal vesicle and vasal pressure responses simultaneously.
| Parameter | Guideline |
|---|---|
| Recommended Dose | 30 mg to start; possible increase to 60 mg if needed |
| Timing Before Sex | 1 to 3 hours prior |
| Frequency of Use | No more than once per day |
| Consumption with Food | Usually taken with or without food, consistency advised |
| Alcohol Interaction | Avoid alcohol; increases side effects |
| Precautions | Not suitable for certain health conditions, consult doctor |
Effect of acute dapoxetine administration on the pudendal motoneuron reflex in anesthetized rats: comparison with paroxetine.
- Men should be aware of potential allergic reactions such as rash or swelling.
- Dapoxetine does not affect sexual desire directly.
- It is important to report any persistent or worsening side effects.
- Use caution when scaling doses up, only as advised by a healthcare professional.
- Avoid taking dapoxetine with other medications that affect serotonin levels.
- Stay informed about new research and updates on dapoxetine therapy.
Brainstem microstimulation differentially inhibits pudendal motoneuron reflex inputs. Supraspinal site of action for the inhibition of ejaculatory reflex by dapoxetine. Effect of dapoxetine on ejaculatory performance and related brain neuronal activity in rapid ejaculator rats.
Counseling and Sex Therapy
Clinical follow-up of couples treated for sexual dysfunction. Arch Sex Behav 1985;14:467-89. Berkovitch M, Keresteci AG, Koren G. Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. Henry R, Morales A, Wyllie MG.
Search strategy
TEMPE: Topical Eutectic-Like Mixture for dapoxetine tadalafil tablets Premature Ejaculation. Expert opinion on drug delivery 2008;5:251-61. Porst H. An overview of pharmacotherapy in premature ejaculation. J Sex Med 2011;8:335-41. Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. Dapoxetine for the treatment of men with premature dapoxetine 60 mg buy online ejaculation (PE): dose-finding analysis. Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med 2010;7:256-68.
- Combining dapoxetine with recreational drugs can be dangerous and is not recommended.
- Dapoxetine can improve quality of life in men with PE.
- Always consult a healthcare provider before starting or stopping medication.
- Maintain open communication with your partner about treatment options.
- Lifestyle adjustments, like reducing stress, can complement medication treatment.
- Regular health screenings are advised during dapoxetine therapy.
Efficacy and safety of dapoxetine for the treatment of premature ejaculation: integrated analysis of results from five phase 3 trials. J Sex Med 2011;8:524-39.
- Dapoxetine's effectiveness peaks when taken on an empty stomach.
- It is classified as a selective serotonin reuptake inhibitor (SSRI).
- The medication’s half-life is short, leading to quick clearance from the system.
- Dapoxetine does not cure premature ejaculation but manages symptoms temporarily.
- Possible temporary side effects include mild nausea and dizziness.
- Do not exceed the recommended dose to avoid adverse effects.
Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials.
INFORMATION ABOUT DAPOXETINE
Dysregulation of emotions and premature ejaculation (PE): alexithymia in 100 outpatients. J Sex Med 2007;4:1462-7. A new combination treatment for premature ejaculation: a sex therapist’s perspective. Feige AM, Pinsky MR, Hellstrom W. Dapoxetine for premature ejaculation.
Recent Post
Emerging treatments for premature ejaculation: focus on dapoxetine. de Carufel F, Trudel G. Effects of a new functional-sexological treatment for premature ejaculation. Rapid ejaculation: a review of conceptual, etiological, and treatment issues. Arch Sex Behav 1995;24:447-72. Dapoxetine for the treatment of premature ejaculation: results from a randomized, Double-Blind, Placebo-Controlled phase 3 trial in 22 countries.
| Aspect | Details |
|---|---|
| Drug Class | Selective Serotonin Reuptake Inhibitor (SSRI) |
| Mechanism of Action | Increases serotonin levels in the nervous system, delaying ejaculation |
| Half-Life | Approximately 19 hours |
| Metabolism | Liver (via CYP enzymes) |
| Excretion | Primarily in urine |
| Interaction Potential | May interact with other serotonergic drugs |
Treatment benefit of dapoxetine for premature ejaculation: results from a placebo-controlled phase III trial. Editorial comment on: Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Baseline characteristics and treatment outcomes for men with acquired or lifelong premature ejaculation with mild or no erectile dysfunction: integrated analyses of two phase 3 dapoxetine trials. Dapoxetine treatment in patients with lifelong premature ejaculation: the reasons of a “Waterloo”. Results from a Prospective Observational Study of Men with Premature Ejaculation Treated with Dapoxetine or Alternative Care: The PAUSE Study. Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors. International Journal of Impotence Research 2006;18:104-10. Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study. Full title A Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study of the Efficacy and Safety of Dapoxetine in Men With Premature Ejaculation and Concomitant Erectile Dysfunction Treated With a Phosphodiesterase-5 Inhibitor COUPLE: COncomitant Use of PriLigy in Men Treated for Erectile Dysfunction A Prospective, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study of the Efficacy and Safety of Dapoxetine in Men With Premature Ejaculation and Concomitant Erectile Dysfunction Treated With a Phosphodiesterase-5 Inhibitor COUPLE: COncomitant Use of PriLigy in Men Treated for Erectile Dysfunction Sponsor organisation Janssen Cilag International N.V. Research summary Premature ejaculation (PE)in men with underlying erection problems affects a substantial number of men. The standard treatment for erection problems is the use of drugs called PDE-5 inhibitors (for example, Viagra, Cialis and Levitra). At present it is not clear whether adding the new drug dapoxetine in men whose underlying erectile dysfunction (ED) has been successfully treated will improve their symptoms of premature ejaculation. Dapoxetine is the only drug in its class which can be used on an "as needed" basis.
