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In particular, make sure that you discuss any of the following. Tell your healthcare provider if you have any of the following. Drink alcohol or use drugs, including a history of drug or alcohol misuse Current or history of mental health problems, including depression It is not known if or how Addyi could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant.
| Side Effect | Frequency | Severity |
|---|---|---|
| Dizziness | Common | Mild to Moderate |
| Nausea | Common | Mild |
| Fatigue | Moderate | Mild |
| Sleepiness | Moderate | Mild |
It is not known if Addyi passes into breast milk.
- Direct comparison trials between flibanserin and bremelanotide are lacking.
- Choice of treatment depends on patient preference, risk profile, and cost.
- Psychological and interpersonal factors are important contributors to HSDD.
- Combining medication with sex therapy or counseling may improve outcomes.
- Flibanserin does not increase libido in individuals without HSDD.
- It is not approved or intended for use as a recreational or enhancement drug.
- Off-label use, such as in postmenopausal women or men, is not supported by evidence.
- Healthcare providers must complete an online knowledge assessment for REMS certification.
- Certification must be renewed periodically according to the REMS program.
Tell your healthcare provider if you are breastfeeding or plan to breastfeed.
Black Box Warnings .
Tell your healthcare provider if you have any of these side effects that bother you. There may be other side effects of Addyi that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345.
Interactions with Food/Tobacco/Alcohol
While less common, the most serious side effects of Addyi are described below, along with what to do if they happen. Addyi may cause allergic reactions, which can be serious. Stop taking Addyi and get help right away if you have any of the following symptoms of a serious allergic reaction. Swelling of the face, lips, mouth, tongue, or throat Itching, skin rash, or pale red bumps on the skin called hives Addyi may slow down your central nervous system (CNS), which controls many vital functions throughout the body. Call your healthcare provider right away if you have any of the following symptoms of CNS depression. Your healthcare provider will advise you if you should stop breastfeeding or stop Addyi. For more information about Addyi, you can visit the manufacturer’s website at or call them at 844-PINK-PILL (844-746-5745).
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You should not eat or drink anything with grapefruit or grapefruit juice in it while taking Addyi. Grapefruit can increase blood levels of Addyi in your body and increase your risk of low blood pressure and fainting. Alcohol can increase your risk of low blood pressure and fainting with Addyi.
Brand names
Addyi can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination for at least six hours after taking Addyi and until you know how Addyi affects you. If you feel faint or dizzy, lie down. The risk of low blood fildena professional 100 pressure or fainting can be increased if you drink alcohol or take certain medicines with Addyi. Tell your healthcare provider right away if you have any of the following symptoms of low blood pressure.
Pharmacogenetic associations and support therapeutic management recommendations
People who are allergic to any of the following should not take Addyi. Any of the ingredients in the specific product dispensed Your pharmacist can tell you all of the ingredients in Addyi. Addyi should not be taken while you are using certain other medicines. Before taking Addyi, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details. You should wait at least two hours after drinking two or fewer standard alcoholic drinks before taking Addyi at bedtime. If you have had three or more drinks with alcohol in them, you should skip your dose of Addyi that evening.
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and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at The exact mechanism of action of flibanserin is unknown. Here is basic information about this medication. Treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is NOT due to: A co-existing medical or psychiatric condition The effects of a medication or other drug substance Recommended: 100 mg orally taken once daily at bedtime Discontinue treatment after 8 weeks if no improvement Moderate or strong cytochrome P450 3A4 (CYP3A4) inhibitors Please refer to the full Prescribing Information (see link below) before prescribing this medication. Disclaimer: The content on this website is provided as general education for medical professionals.
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It is not intended or recommended for patients or other laypersons or as a substitute for medical advice, diagnosis, or treatment. Patients must always consult a qualified health care professional regarding their diagnosis and treatment. Healthcare professionals should always check this website for the most recently updated information. Overview: Addyi is used in certain women to treat low sex drive (hypoactive sexual desire disorder or HSDD). It seems to work by balancing chemicals in the brain, including dopamine, norepinephrine, and serotonin. Once you have taken Addyi in the evening, you should not drink any alcohol until at least the next day.
- Clinical trials excluded women with many comorbidities (e.g., unstable medical conditions).
- Real-world effectiveness in broader populations may differ from trial results.
- Patient satisfaction with treatment can vary widely.
- Some women report significant improvement in sexual desire and distress.
- Others discontinue due to side effects or lack of meaningful benefit.
- Adherence to daily dosing is a challenge for some patients.
- The bedtime dosing schedule is intended to mitigate side effects like dizziness.
- Taking it with a high-fat meal can increase absorption and side effect risk.
- Should be taken on an empty stomach, at least 2 hours after a high-fat meal.
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
IMPORTANT WARNING:
This may decrease your risk for fainting, because you will be lying down already. If you have been taking Addyi for eight weeks or more and it is not improving your symptoms, tell your healthcare provider. Your healthcare provider may advise you to stop taking it. Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Addyi is right for you. In particular, make sure that you discuss if you are using any of the following before taking Addyi.
- Flibanserin, a serotonin receptor modulator, was initially investigated for depression.
- Its approval marked a historic moment in treating female sexual dysfunction.
- The medication's side effects necessitate careful patient education.
- Efficacy is often supported by patient-reported improvements in desire.
- It does not function as an aphrodisiac but affects brain chemistry.
- Flibanserin therapy requires adherence to dosing instructions.
- Women with low libido due to other health issues may not benefit from it.
- Its role is to complement behavioral or psychological therapy if needed.
- Research continues into better options for treating female hypoactive sexual desire.
Any other medicine that causes dizziness and sleepiness, such as prescription pain medicines, sleep medicines, and medicines for anxiety Ketoconazole, itraconazole (Sporanox, Tolsura), posaconazole (Noxafil), fluconazole (Diflucan), or voriconazole (Vfend), which is a medicine used for fungal infections Clarithromycin, erythromycin, or ciprofloxacin, which is an antibiotic used for bacterial infections Diltiazem (Cardizem CD and others) or verapamil (Verelan, Verelan PM), which is a medicine used for high blood pressure and other conditions Any medicine for seizures, such as carbamazepine, phenytoin, or phenobarbital A selective serotonin reuptake inhibitor (SSRI), such as fluoxetine, paroxetine, or sertraline, which is a medicine commonly used for anxiety and depression A medicine for HIV, AIDS, or hepatitis C Cimetidine, ranitidine, or a proton pump inhibitor (PPI), such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), or rabeprazole (Aciphex) Rifampin (Rifadin) or rifapentine (Priftin), which is a medicine commonly used to treat an infection called tuberculosis Rifabutin (Mycobutin), which is a medicine used to prevent Mycobacterium avium complex infection Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure Nefazodone, which is used to treat depression Conivaptan (Vaprisol), which is used to treat low blood sodium levels St. John’s wort, which is a supplement that may be used to treat depression Ginkgo, which is a supplement used for memory and blood flow Resveratrol, which is a supplement used for weight loss and allergies Sirolimus (Rapamune), which is commonly used to prevent rejection of a transplanted organ A benzodiazepine, such as clonazepam (Klonopin), diazepam (Valium and others), or lorazepam (Ativan and others), which is a medicine used for anxiety, muscle spasms, or seizures Many other medicines may alter the blood levels of Addyi, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
Proper use of flibanserin
Common side effects include nausea, sleepiness, and dizziness. Serious side effects are rare, but can include low blood pressure and fainting. It is important to tell your healthcare provider about all of the medicines you take before and while taking Addyi. Addyi (flibanserin) is commonly used to treat low sex drive (hypoactive sexual desire disorder or HSDD) in women less than 65 years of age who have not had problems with low sexual desire in the past and have low sexual desire no matter the type of sexual activity or partner. It is not for people whose low sex drive is caused by medical or mental health problems, relationship problems, or medicines or drug use.
Does Addyi interact with foods or drinks?
Addyi may also be used for other conditions as determined by your healthcare provider. Addyi seems to work by balancing brain chemicals that affect sex drive, such as dopamine, norepinephrine, and serotonin. Addyi should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. The most common side effects of Addyi are listed below. This may not be a complete list of medicines that can interact with Addyi.
- In 2019, the FDA required updates to the prescribing information regarding liver injury.
- Cases of hepatitis and liver enzyme elevations were reported post-marketing.
- Patients should be monitored for symptoms of liver injury (jaundice, dark urine).
- Discontinue flibanserin if liver injury is suspected.
- The REMS was modified to strengthen the warning about hepatotoxicity.
- Patients with signs of liver disease should not start flibanserin.
- Baseline liver enzyme testing is now considered a standard part of patient assessment.
- Follow-up testing may be recommended based on clinical judgment.
- The overall incidence of serious liver injury appears to be low.
If you or someone else has used too much Addyi, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222. Take the next dose at bedtime the next day. Do not take double or extra doses. This survey is being conducted by the WebMD marketing sciences department. DOI: 10.1016/j.eururo.2015.09.050 External LinkAlso available on ScienceDirect External Link The US Food and Drug Administration has approved Addyi (flibanserin) for treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.
Warnings & Precautions
Addyi should not be taken if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine. Do not take Addyi unless it has been prescribed to you by a healthcare provider. Do not share Addyi with other people, even if they have the same condition as you. Keep Addyi out of the reach of children.
