Sildenafil Citrate 50mg Tablet
The primary indication of sildenafil is treatment of erectile dysfunction
Product Specification
[8] Rare but serious side effects include vision problems, hearing loss, and prolonged erection (priapism) that can lead to damage to the penis. [8] Sildenafil should not be taken by people on nitric oxide donors sildenafil citrate tablet such as nitroglycerin, as this may result in a serious drop in blood pressure. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis. [8] It requires sexual arousal to work, and does not by itself cause or increase sexual arousal. [8] It also results in dilation of the blood vessels in the lungs.
Pregnancy Categories
Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998. [5][8][11][12] In 2023, it was the 151st most commonly prescribed medication in the United States, with more than 3 million prescriptions. [13][14] It is available as a generic medication. [15][16] In the United Kingdom, it is available as a pharmacy medicine. (inability to sustain a satisfactory erection to complete sexual intercourse).
- Do not take sildenafil if you are on nitrate medications for chest pain.
- Using both can cause a dangerous drop in blood pressure.
- Always inform your doctor about all medications you are taking.
Its use is now one of the standard treatments for erectile dysfunction, including for males with diabetes mellitus.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Polo | 100mg | 20 Pills | 83.56€ 79.58€ | |
| Kamagra | 100mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Kamagra | 100mg | 20 Pills | 86.09€ 81.99€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Kamagra Soft Tabs | 100mg | 60 + 4 Pills | 180.59€ 171.99€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ | |
| Kamagra Soft Tabs | 100mg | 20 Pills | 79.79€ 75.99€ | |
| Kamagra Soft Tabs | 100mg | 84 + 4 Pills | 233.05€ 221.95€ | |
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| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Viagra Generic | 25mg | 60 + 4 Pills | 71.99€ 68.56€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ |
Tentative evidence suggests that sildenafil may
- Sildenafil works by relaxing blood vessels in the penis.
- It requires sexual stimulation to be effective.
- Consult a doctor before starting to ensure safety.
help males who experience antidepressant-induced erectile dysfunction.
| Patient Group | Recommended Dose | Notes |
|---|---|---|
| Adults (18-65) | 50 mg prior to activity | Max once per day |
| Elderly (>65) | 25-50 mg as needed | Adjust based on tolerability |
| Patients with Liver Impairment | Start at 25 mg | May need dose reduction |
| Patients on CYP3A4 inhibitors | Lower dose | Due to increased plasma levels |
While sildenafil improves some markers of
Detection in biological fluids
They’ll likely recommend you do not take riociguat with sildenafil. * For more details about this side effect, see the “Sildenafil: Serious side effects” section above. It’s unknown whether sildenafil is safe to take while pregnant or breastfeeding. Animal studies* did not show harm to the fetus when the drug was exposed to pregnant animals. However, keep in mind that animal studies don’t always reflect what will happen in humans.
Interactions that increase your risk for side effects
If you’re pregnant or can become pregnant, talk with your doctor. They’ll review the risks and benefits with you and advise whether sildenafil treatment is right for you. In certain oral sildenafil cases, your doctor may recommend that you continue taking sildenafil during pregnancy. Sildenafil may pass into breast milk, but it isn’t known how this could affect a child who is breastfed. If you are breastfeeding or planning to breastfeed, talk with your doctor. disease in people with pulmonary arterial hypertension,
6.1 Clinical Trials Experience
The use of both could cause major heart problems. • Also, the use of CYP3A4 or P450 inhibitors (which are the cytochromes responsible for Viagra metabolism), greatly increases the risk of negative side effects. ADVERSE EFFECTS- • HEADACHE •NASAL CONGESTION • DIZZINESS • FLUSHING • FALL IN BP • LOOSE MOTIONS • IMPAIRMENT OF COLOUR DISCRIMINATION PHARMACOKINETICS • Sildenafil citrateis rapidly absorbed after oral administration - Total Bioavailability: 40% • Its pharmacokinetics are dose proportional over the recommended range • Sildenafil citrate is metabolized mainly by hepatic metabolism and excreted mainly in the feces. Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4][8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon.
Does Sildenafil Citrate affect sperm?
[9] It is unclear if it is effective for treating sexual dysfunction in females. [8] It can be taken orally (swallowed by mouth), intravenously (injection into a vein), or through the sublingual route (dissolved under the tongue). [8][10] Onset when taken orally is typically within twenty minutes and lasts for about two hours. Common side effects include headaches, heartburn, and flushed skin. [8] Caution is advised in those with cardiovascular disease. it does not appear to affect the risk of death or serious side effects.
2.1 Recommended Dosage in Adults
For details about your condition, see our hypertension hub. You can also view our men’s health hub and this list of erectile dysfunction and premature ejaculation articles. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication.
Cardiovascular problems
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Sildenafil Citrate DR. MANOJKUMAR SINGH 1ST YR PG PHYSICAL MEDICINE AND REHABILITATION PMCH PATNA HISTORY- • Pfizer originallysought for a PDE inhibitor that might act as a new antihypertensive and antianginal drug. • Studies were done to see what side effects would come from increased dosages. Sildenafil and other PDE5 inhibitors are used off-label to alleviate
Overdose/Missed Dose
Volunteers reported back with side effects like head aches, visual problems, and prolongment of penile erections. • According to the British Press, but not Pfizer, Peter Dunn and Albert Wood invented sildenafil. • Hydrolysis with NaOH • Nitration with fuming Nitric Acid • Carboxamide formation with refluxing thionyl chloride/ NH4OH • sildenafil oral strips Reduction of Nitro group to Amino • Acylation with 2-ethoxybenzoyle chloride • Cyclization • Sulfonation to the chlorosulfonyl derivative • Condesation with 1-methylpiperazine MEDICAL USES- *ERECTILE DYSFUNCTION *PULMONARYHYPERTENSION * prevention and treatment of high-altitude pulmonary edema associated with altitude sickness. NONMEDICAL USE- * Recreationaluse belief that the drug increases libido, improves sexual performance, or permanently increases penis size *Jet lag research * Sports * Analogs Acetildenafil is a structural analog of sildenafil, one of the PDE5 inhibitors found in a number of "herbal" aphrodisiac products sold over-the-counter. ERECTILE DYSFUCTION- • Initialdose: 50 mg orally once a day, as needed, 1 hour prior to sexual activity • Maintenance: 25 to 100 mg orally once a day, as needed, 1 hour prior to sexual activity.
Does Sildenafil Citrate increase blood pressure?
HYPERTENSION DOSE- •Initial dose: 5 or 20 mg orally three times a day, 4 to 6 hours apart • -Maximum dose: 20 mg orally three times a day • Injection: • -Initial dose: 2.5 or 10 mg IV bolus three times a day. Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection CONTRAINDICATION- • When takingnitric oxide donors, organic nitrites and nitrates, such as glyceryl trinitrate (nitroglycerin), sodium nitroprusside, amyl nitrite. • In men for whom sexual intercourse is inadvisable due to cardiovascular risk factors • Severe hepatic impairment (decreased liver function) • Severe impairment in renal function • Hypotension (low blood pressure) • Recent stroke or heart attack • Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases) • Because sildenafilis a vasodilator (although mainly locally), it needs to be used cautiously because it lowers blood pressure. • Viagra should not be given to patients who are taking nitrates, because nitrates are also a strong vasodilator. vasospasm and treat severe ischemia and ulcers in fingers and
| Brand Name | Manufacturer | Country of Origin | Availability |
|---|---|---|---|
| Viagra | Pfizer | USA | Widely available |
| Kamagra | Ajanta Pharma | India | Limited markets |
| Sildenafil Sandoz | Novartis | Switzerland | Prescription only |
| Revatio | Pfizer | USA | For pulmonary hypertension |
| Bedrocan | Canadian Medical Cannabis | Canada | Not for oral use |
toes for people with secondary Raynaud's phenomenon;[9][21] these drugs have
- Sildenafil citrate was initially developed for hypertension and angina.
- It was later discovered to be effective for erectile dysfunction.
- The drug was approved by the FDA for ED treatment in 1998.
moderate efficacy for reducing the frequency and duration of vasospastic episodes.
- If you miss a dose and have planned sexual activity, take it as soon as possible.
- Do not double doses to make up for missed ones.
- Follow your prescription guidelines for safe and effective use.
[9] As of 2016,[update] their role more generally in Raynaud's was not clear.
In case of emergency/overdose
These conditions may increase your risk of severe priapism* during sildenafil treatment. If you experience an erection lasting longer than 4 hours, call 911 or your local emergency number immediately. If you take nitrates for any reason. Taking sildenafil with drugs containing nitrates is contraindicated. (A contraindication is a factor or condition that could prevent your doctor from prescribing a drug due to risk of harm.) This is due to sildenafil’s potential to cause severe low blood pressure.
Pulmonary Arterial Hypertension
* Examples of nitrates include nitroglycerin (Nitrolingual), isosorbide (Isordil), nitroprusside (Nitropress). If you take any of these drugs or any other nitrates, be sure to tell your doctor before starting sildenafil treatment. Sildenafil is contraindicated if you take a GC stimulator, including riociguat (Adempas). This is because these drugs may cause severe low blood pressure. Be sure to tell your doctor if you take this drug. Sildenafil has shown some potential for improving exercise performance at high altitudes.
| Country | Approval Status | Notable Regulations |
|---|---|---|
| USA | Approved | Prescription required |
| European Union | Approved | Prescription-only, monitoring recommended |
| Canada | Approved | Prescription only |
| India | Approved | Over the counter in some regions |
| Australia | Approved | Restricted to prescription use |
However, its overall efficacy is not clear.
Dosing & Uses
They can review the risks and benefits of taking sildenafil while breastfeeding. If you are taking sildenafil for erectile dysfunction or pulmonary arterial hypertension, it’s possible to experience side effects. Most side effects are mild to moderate in severity. If you’re experiencing symptoms of severe side effects while taking sildenafil, talk with your doctor right away. If you’d like to learn more about sildenafil, talk with your doctor or pharmacist.
Revatio Injection
They can help answer any questions you have about side effects from taking the drug. A generic drug and its brand-name version contain the same active ingredient, so they’re expected to have the same side effects. Referring to the following articles about sildenafil and Viagra can provide you with additional information: For details about other aspects of sildenafil, refer to this article. To learn how sildenafil compares with Viagra, read this article. If you’d like to learn about sildenafil and cost, see this article.
