Label: SILDENAFIL- sildenafil tablet, film coated

In the United States,

• The pink sildenafil pill is often used recreationally.
• Overuse can lead to adverse health effects.
• It doesn't increase libido but improves erectile response.
• Food intake can delay the pill’s effectiveness.
• The medication should not be mixed with alcohol.
• It is possible to develop dependence with frequent use.

Pfizer received two patents

Dosage and Administration:

As of 2018[update], the US Food and Drug Administration has approved fifteen drug manufacturers to market generic sildenafil in the United States. Seven of these companies are based in India. The patent for Pfizer's Viagra sildenafil to treat erectile dysfunction expired in April 2020. In 2026 a chocolate syrup called Boner Bears from Lockout Supplements was recalled through the FDA because of it containing Sildenafil as an undisclosed ingredient. Counterfeit Viagra, despite generally being cheaper,[88] can contain harmful substances or substances that affect how Viagra works, such as blue printer ink, amphetamines, metronidazole, boric acid, and rat poison.

Marketing and sales

Viagra is one of the world's most counterfeited medicines. [90][91] According to a 2012 Pfizer study, around 80% of sites claiming to sell Viagra were selling counterfeits. An October 2023 release stated that erectile dysfunction medicines were the most seized drugs by the Interpol[92] accounting for 22% of seizures. In 1992, Pfizer filed a patent covering the substance sildenafil and its use to treat cardiovascular diseases. [96] This would be marketed as Revatio. for sildenafil: one for

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Viagra Generic	100mg	180 + 8 Pills	199.37€ 189.88€	Buy
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Kamagra Oral Jelly	100mg	63 + 7 Sachets	224.18€ 213.50€	Buy
Kamagra Polo	100mg	12 Pills	60.21€ 57.34€	Buy
Kamagra Soft Tabs	100mg	32 Pills	120.11€ 114.39€	Buy
Kamagra Polo	100mg	120 + 6 Pills	327.15€ 311.57€	Buy
Viagra Generic	50mg	10 Pills	26.87€ 25.59€	Buy
Viagra Generic	150mg	30 + 2 Pills	72.32€ 68.88€	Buy
Viagra Generic	50mg	30 + 4 Pills	54.26€ 51.68€	Buy
Viagra Generic	50mg	90 + 6 Pills	107.37€ 102.26€	Buy

its indication to treat

5.8 Effects on Bleeding

Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4 (major route), but also by CYP2C9 (minor route) hepatic isoenzymes. The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

Pulmonary hypertension

If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third. When taken orally, sildenafil for erectile dysfunction results in an average time to onset of erections of 27 minutes (ranging from 12 to 70 minutes). Sublingual use of sildenafil for erectile dysfunction results in an average onset of action of 15 minutes and lasting for an average of 40 minutes. The preparation steps for synthesis of sildenafil are:[54] Methylation of 3-propylpyrazole-5-carboxylic acid ethyl ester with hot dimethyl sulfate Hydrolysis with aqueous sodium hydroxide (NaOH) to free acid Carboxamide formation with refluxing thionyl chloride/NH4OH Reduction of nitro group to amino group Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists led by Simon Campbell[55] working at Pfizer's Sandwich, Kent, research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease).

Liver impairment

[56] The first clinical trials were conducted in Morriston Hospital in Swansea. [57] Phase I clinical trials under the direction of Ian Osterloh suggested the drug had little effect on angina, but it could induce marked penile erections. [58][59] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina; this decision became an often-cited example of drug repositioning. [60][61] The drug was patented in 1996, approved for use in erectile dysfunction by the FDA on 27 March 1998, becoming the first oral treatment approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year. [62] It soon became a great success: annual sales of Viagra peaked in 2008 at US$1.934 billion. cardiovascular disease (marketed as

• The pink sildenafil pill enhances sexual performance.
• It is not a cure for erectile dysfunction but alleviates symptoms.
• The effect begins within 30 minutes for most users.
• The pink color is a marketing feature to distinguish brands.
• Use it responsibly to avoid dependency or side effects.
• Always adhere to prescribed doses for safety.

Revatio) and another for

Condition	Ideal Range	Notes
Temperature	20-25°C (68-77°F)	Keep away from heat & moisture
Humidity	Below 60% humidity	Prevent degradation
Light Exposure	Store in dark, opaque container	Prevent color or potency loss
Container	Airtight, child-resistant container	Keep out of reach of children

its indication to treat

5.1 Cardiovascular

[42] Some attempts have been made to ban these drugs, but progress has been slow so far, as, even in those jurisdictions that have laws targeting designer drugs, the laws are drafted to ban analogs of illegal drugs of abuse, rather than analogs of prescription medicines. However, at least one court case has resulted in a product being taken off the market. The US Food and Drug Administration (FDA) has banned numerous products claiming to be Eurycoma longifolia that, in fact, contain only analogs of sildenafil. [44][45][46] Sellers of such fake herbals typically respond by just changing the names of their products. Sildenafil and/or N-desmethylsildenafil, its major active metabolite, may be quantified in plasma, serum, or whole blood to assess pharmacokinetic status in those receiving the drug therapeutically, to confirm the diagnosis in potential poisoning victims, or to assist in the forensic investigation in a case of fatal overdose.

What are the most common side effects of sildenafil?

Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection. [49] Robert F. Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation. The molecular mechanism of smooth muscle relaxation involves the enzyme CGMP-dependent protein kinase, also known as PKG.

Incidence not known

This kinase is activated by cGMP and it phosphorylates multiple targets in the smooth muscle cells, namely myosin light chain phosphatase, RhoA, IP3 receptor, phospholipase C, and others. [50] Overall, this results in a decrease in intracellular calcium and desensitizing proteins to the effects of calcium, engendering smooth muscle relaxation. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and increased penile response to sexual stimulation. [49][51] Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). erectile dysfunction (marketed as Viagra).

Aspect	Effect	Time to Max Effect	Reports of Increased Blood Flow	Notes
Vasodilation	Relaxes blood vessel muscles	1 hour	Commonly observed	Leads to erection
Penile Blood Flow	Increased in response to stimulation	30-60 minutes	Consistently reported	Enhances erectile function
Duration of increased blood flow	Up to 6 hours	Varies	Depends on dosage and individual