Label: VARDENAFIL tablet, orally disintegrating

St John's Wort will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. terazosinvardenafil increases effects of terazosin by pharmacodynamic synergism. vardenafil increases effects of terazosin by pharmacodynamic synergism.

• Vardenafil 10 mg is a selective phosphodiesterase type 5 inhibitor.
• It can improve the ability to achieve an erection.
• Maintain open communication with your healthcare provider.
• Use with caution in elderly patients.
• Report any unusual side effects promptly.
• The medication should not be used recreationally.
• Not recommended for use with certain antihypertensives.
• Effectiveness depends on correct timing and dosage.
• Avoid taking if you have severe liver disease.
• Always read the patient information leaflet.

tetrabenazinetetrabenazine and vardenafil both increase QTc interval. tetrabenazine and vardenafil both increase QTc interval. tovorafenibtovorafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of tovorafenib (a weak CYP3A4 inducer) with CYP3A substrates where minimal concentration changes may lead to serious therapeutic failures. If unavoidable, monitor patients for loss of efficacy unless otherwise recommended in the CYP3A4 substrate prescribing information. tovorafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tucatinibtucatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities.

• The onset of vardenafil 10 mg is typically 30-60 minutes.
• It can last up to 4-5 hours in some users.
• Vardenafil is contraindicated with certain heart medications.
• Use caution if you have a history of hypotension.
• The tablet may cause mild gastrointestinal upset.
• Do not consume large amounts of alcohol when taking vardenafil.
• Inform your doctor if you experience sudden hearing loss.
• Use only as directed by your healthcare provider.
• Discontinue if you experience persistent erection issues.
• The medication does not increase sexual desire.

If unavoidable, reduce CYP3A substrate dose according to product labeling. tucatinib will vardenafil tablets increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. vardenafil increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval.

Drug Name	Dose Range	Duration of Action	Onset Time	Special Features
Vardenafil	5-20 mg	4-5 hours	30-60 min	Fast onset, good for food timing
Sildenafil	25-100 mg	4-6 hours	30-60 min	Well-studied, widespread use
Tadalafil	2.5-20 mg	Up to 36 hours	30-120 min	Long duration, daily options
Avanafil	50-200 mg	4-6 hours	15-30 min	Fastest onset, fewer side effects

Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended. vilanterol/fluticasone furoate inhaledvardenafil increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. vardenafil increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Avoid coadministration of ziftomenib with other drugs known to prolong the QTc interval. If unavoidable, obtain ECGs when initiating, during concomitant use, and as clinically indicated. Interrupt ziftomenib with QTc interval > 500 ms or a change from baseline is > 60 ms vardenafil and ziftomenib both increase QTc interval. Interrupt ziftomenib with QTc interval > 500 ms or a change from baseline is > 60 ms zotepinevardenafil increases effects of zotepine by pharmacodynamic synergism.

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mefloquine increases toxicity of vardenafil by QTc interval. vardenafil and milsaperidone both increase QTc interval. moxisylytevardenafil increases effects of moxisylyte by pharmacodynamic synergism. vardenafil increases effects of moxisylyte by pharmacodynamic synergism. ondansetronondansetron and vardenafil both increase QTc interval.

What are the side effects of vardenafil?

ondansetron and vardenafil both increase QTc interval. oxaliplatin and vardenafil both increase QTc interval. phenoxybenzaminevardenafil increases effects of phenoxybenzamine by pharmacodynamic synergism. vardenafil increases effects of phenoxybenzamine by pharmacodynamic synergism. phentolaminevardenafil increases effects of phentolamine by pharmacodynamic synergism. vardenafil increases effects of zotepine by pharmacodynamic synergism.

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adagrasibadagrasib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors adagrasib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors alfuzosinvardenafil and alfuzosin both increase QTc interval. Use Caution/Monitor.alfuzosin and vardenafil both increase QTc interval.

What is the current market landscape for vardenafil hydrochloride?

Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation. macimorelinmacimorelin and vardenafil both increase QTc interval. Macimorelin causes an increase of ~11 msec in the corrected QT interval.

Vardenafil Medication Description

Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. macimorelin and vardenafil both increase QTc interval. mefloquinemefloquine increases toxicity of vardenafil by QTc interval. Mefloquine may enhance the QTc prolonging effect of high risk buy cenforce 120mg QTc prolonging agents. vardenafil and alfuzosin both increase QTc interval.

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Withhold if QTc interval >500 ms or a change from baseline >60 ms. vardenafil and givinostat both increase QTc interval. hydroxychloroquine sulfate and vardenafil both increase QTc interval. idelalisibidelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates idelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Drug Interactions

Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates iloperidonevardenafil and iloperidone both increase QTc interval. isoflurane and vardenafil both increase QTc interval. itraconazoleitraconazole and vardenafil both increase QTc interval. itraconazole and vardenafil both increase QTc interval. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. Monitor blood pressure response to phosphodiesterase type 5 (PDE5) inhibitors in patients receiving concurrent blood pressure lowering therapy. amiodaroneamiodarone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors amiodarone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors apomorphineapomorphine and vardenafil both increase QTc interval.

5.7 Congenital or Acquired QT Prolongation

vardenafil increases effects of phentolamine by pharmacodynamic synergism. prazosinvardenafil increases effects of prazosin by pharmacodynamic synergism. vardenafil increases effects of prazosin by pharmacodynamic synergism. ribociclibribociclib increases toxicity of vardenafil by QTc interval. ribociclib increases toxicity of vardenafil by QTc interval. apomorphine and vardenafil both increase QTc interval.

Region	Average Price (per tablet)	Availability	Notes
North America	$2 - $5	Widely available	Prescription required
Europe	€2 - €4	Available at pharmacies	Generic options common
Asia	$1 - $3	Readily available	Often lower cost
Africa	$2 - $4	Varies by country	May require import or special order

aprepitantaprepitant will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors aprepitant will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors aripiprazolearipiprazole and vardenafil both increase QTc interval.

Before taking this medicine

rifabutinrifabutin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifabutin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifampinrifampin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifampin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sevofluranesevoflurane and vardenafil both increase QTc interval. aripiprazole and vardenafil both increase QTc interval. armodafinilarmodafinil will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Dosing & Uses

clarithromycin and vardenafil both increase QTc interval. danazoldanazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. danazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxazosinvardenafil increases effects of doxazosin by pharmacodynamic synergism. vardenafil increases effects of doxazosin by pharmacodynamic synergism.

Vardenafil Side Effects

entrectinib and vardenafil both increase QTc interval. eribulin and vardenafil both increase QTc interval. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval. givinostatvardenafil and givinostat both increase QTc interval. If unable to avoid coadministration, obtain ECGs when initiating, during concomitant use, and as clinically indicated. armodafinil will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether/lumefantrineartemether/lumefantrine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether/lumefantrine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. asenapinevardenafil increases effects of asenapine by pharmacodynamic synergism. vardenafil increases effects of asenapine by pharmacodynamic synergism.

7.1 Potential for Pharmacodynamic Interactions with Vardenafil Hydrochloride Orally Disintegrating Tablets

sevoflurane and vardenafil both increase QTc interval. silodosinvardenafil increases effects of silodosin by pharmacodynamic synergism. vardenafil increases effects of silodosin by pharmacodynamic synergism. siponimod and vardenafil both increase QTc interval. St John's WortSt John's Wort will decrease the vardenafil pills level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. atazanaviratazanavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.